Thomas Little, M.D., F.A.C.C., F.S.C.A.I.


EDUCATION:

B.Sc. McGill University
M.S. Medical Genetics Rutgers University
M.D. Medical College of Georgia

TRAINING:

Internship and Residency in Internal Medicine, State University of New York at Buffalo

Cardiology Research Fellow, State University of New York at Buffalo
Cardiology Fellow, Emory University,
Interventional Cardiology Fellow, Washington Hospital Center


HONORS:

Alpha Omega Alpha national medical honor society
Merck Award
Semmelweiss Research Prize.


BOARD CERTIFICATION

Internal Medicine
Cardiovascular Diseases
Nuclear Cardiology
Interventional Cardiology

SOCIETY MEMBERSHIPS

Fellow, American College of Cardiology.
Fellow, Society of Coronary Angiography and Interventions.
Fellow, American College of Physicians.
Fellow, Council of Geriatric Cardiology.
Member, Clinical Council, American Heart Association.
Member, American Federation for Clinical Research.

BIBLIOGRAPHY

PAPERS PRESENTED AND PUBLISHED IN ABSTRACT FORM

  1. Little T, Faguet GB, Agee JF. Chronic myelogenous leukemia emerging from chronic lymphatic leukemia: Evidence for the evolution of a single clone/ Presented to the American Society of Hematology, San Antonio, TX, 1981. Abstract published in Blood 58 (supplement I):145a, 1981.
  2. Little T, Ellis AK, Masud AZ et al. Non-invasive detection of successful coronary arterial reperfusion in acute myocardial infarction. Presented to the American Federation for Clinical Research, Washington, D.C., 1985. Abstract published in Clincal Research 33;205A, 1985.
  3. Little T, Crenshaw MH, Liberman HA et al. How early in the course of acute myocardial infarction must recombinant tissue plasminogen activator establish reperfusion in order to improve subsequent left ventricular function at rest and during exercise? Presented to the American Federation for Clinical Research, Washington, D.C., 1988. Abstract published in Clinical Research 36:297a, 1988.
  4. Little T, Ellis AK, Liberman HA et al. Non-invasive preduction of successful thrombolysis from plasma myoglobin levels. Presented to the American Federation for Clinical Research, Washington, D.C., 1988. Abstract published in Clinical Research 36:297a, 1988.
  5. Little T, Milner MR, Mukherjee D et al. Coronary angioplasty in octogenarians. Presented to the American Federation for Clinical Research, Eastern Region, New York, New York, 1989. Abstract published in Clinical Research 37:842a, 1989.
  6. Little T, Milner MR, Mukherjee D et al. Coronary angioplasty in octogenarians. Presented to the American College of Cardiology, New Orleans, 1990. Abstract published in Journal of the American College of Cardiology 15:35a, 1990.
  7. Little T, Mukherjee D, Pichard AD et al. Multi-lesion coronary angioplasty in elderly patients. Presented to the American College of Cardiology, Atlanta, GA, 1991. Abstract published in the Journal of the American College of Cardiology 17:150a, 1991.
  8. Meadaa R, John B, Little T. One year survival of octogenarians with unstable angina treated conservatively. Presented to the American Federation for Clinical Research May 1992. Abstract published in Clinical Research 40:254a, 1992.
  9. Little T. Mortality of ischemic heart disease in medicare patients treated medically, interventionally, and surgically after cardiac catheterization. Presented to the American Federation for Clinical Research, Baltimore, MD, 1992. Abstract published in Clin. Res. 40:25a, 1992.
  10. Martin EL, Altujuman AM, little T. Angiographic features of infarct related arteries in single vessel versus multivessel coronary artery disease patients. Abstract published in Clin. Res. 42:100A, 1994.
  11. Youssef A, Little T, Krall J. Long term outcome of conservation treatment of acute myocardial infarction in octogenarians. Abstract published in Clin. Res. 42:101A, 1994.
  12. Majcher G, little T. Use of perfusion catheters to decrese myocardial injury after failed coronary angioplasty. For presentation to the American Federation for Clinical Research, Baltimore, MD, 1994. Abstract published in Clin. Res. 42:194A, 1994
  13. Parhar N, Manja G, Rashid S, Little T. The randomized Easton atrial fibrillation (REAF) trial of procainamide versus Digoxin in recent onset atrial fidrillation. Abstract published in J Investing. Med. 43:510A, 1995.
  14. Abciximab Readministration: Final results of the Reopro Readministration Registry. Presented to the ACC scientific session , Chicago 2003. Abstract published in Circ 41:77A, 2003.

PUBLICATIONS (BOOKS):

  1. Little T. MYOCRADITIS AND DILATED CARDIOMYOPATHY, in Hurst J.W. (ed) The Heart, Companion Handbook, New York, McGraw Hill, pp. 178-186, 1988
  2. Pollack SK, Little T. RECOGNITION AND TREATMENT OF CARDIAC ARRHYTHMIAS AND CONDUCTION ABNORMALITES, in Hurst J.W. (ed) The Heart, Companion Handbook, New York, McGraw Hill, pp. 15-42, 1988

PUBLICATIONS (JOURNALS):

  1. Faguet GV, Little T, Agee JF. Chronic lymphatic leukemia evolving into chronic myelocytic leukemia. Cancer 52:1647-1652, 1983
  2. Ellis AK, Little T, Masud AZ, Klocke FJ. Myoglobin release after reperfusion of injured myocardium. Circulation 72:639-647, 1985
  3. Little T, External cardiac pacing of right ventricular infarction. Annals of Emergency Medicine 17:640-642, 1988.
  4. Ellis AK, Little T, Masud AZ, Lieberman HA, Morris DC, Klocke FJ. Early non-invasive detection of successful reperfusion in patients with acute myocardial infarction. Circulation 78:1352-1357, 1988.
  5. Little T, Pichard AD, Lindsay J. Probe angioplasty of total coronary occlusion using an intracoronary probing catheter. Catheterization and Cardiovascular Diagnosis 17:218-223, 1989.
  6. Milner MR, Gallino RA, Leffingwell A, Pichard AD, Brooks Robinson S, Rosenberg J, Little T, Lindsay J. Usefulness of fish oil supplements in preventing clinical evidence of restenosis after percutaneous transluminal coronary angioplasty. American Journal of Cardiology 64:294-299, 1989.
  7. Litle T, Macoviak J, Villanueva P, Lawrenson WE, Rao A. Diffuse coronary vasospasm and accelerated atherosclerosis in transplanted human heart. American Journal of Cardiology 64:825-827, 1989.
  8. Martinez A, Pichard AD, Little T, Lindsay J. The Probe “balloon on a wire” ultra-low profile coronary catheter: Results of PTCA in 107 patients. Catheterization and Cardiovascular Diagnosis 18:222-226, 1989.
  9. Little T, Pichard AD, Rosenberg J, Seides S, Lindsay J. Probe angioplasty of total coronary occlusions using the Probing Catheter technique. Results in 65 consecutive cases. Catheterization and Cardiovascular Diagnosis 21:124-127,1990.
  10. Little T, Lee K, Mukherjee D, Milner M, Lindsay J. Delayed coronary angioplasty after thrombolytic therapy for acute muyocardial infarction. American Journal of Cardiology 66:1299-60, 1990.
  11. Little T, Clemens S. Electrocardiographic, echocardiographic, computerized tomographic and anatomic abnormalities produced by tumor metastatic to the heart. Emory U J Med 4:8-11, 1990.
  12. Little T, Crenshaw M, Liberman HA et al. Effects of time required for reperfusion (thrombolysis, angioplasty or both) and location of acute myocardial infarction on left ventricular functional reserve capacity several months later. Am J Cardiol 67:797-805, 1991.
  13. Little T, Milner M, Pichard AD, Mukherjee D, Lindsay J Jr. A comparison of percutaneous transluminal coronary angioplasty in elderly (>70 years) and younger subjects. Am Heart J 124:628-630, 1991.
  14. Little T. Coronary angioplasty in elderly patients above age 70. Cardio, September 1991.
  15. Little T. Prolonged coronary splinting in the management of acute coronary closure. Catheter Cardiovasc Diagn 25:213-17, 1992.
  16. Little T, Milner MR, Lee K, Constantine J, Pichard AD, Lindsay J Jr. Late outcome and quality of life following percutaneous transluminal coronary angioplasty in octogenarians. Cathet Cardiovasc Diagn 29:261-266, 1993.
  17. Thavendrarajah V, Ghia P, Kozinn W, Little T. Catheter lavage and drainage of pneumococcal pericarditis. Catheter Cardiovasc Diagn 29:322-324, 1993.
  18. Little T. Mortality of Medicare patients undergoing medical therapy for ischemic heart disease. Cardiol in the Elderly 2:29-33, 1994.
  19. Lindsay J, Venugopal MR, Pinnow EE, Little T, Pichard AD. Morbidity and mortality rates in elderly patients undergoing percutaneous transluminal coronary angioplasty. AM Heart J 128:697-702, 1994.
  20. Little T, Lindsay J. Percutaneous transluminal coronary angioplasty and coronary bypass surgery in octogenarians. Heart Disease and Stroke 3:261-265, 1994.
  21. Little T, Meadaa R, Manja G, John B, Krall J, Cowan J. Long term outcome of octogenarians with unstable angina treated conservatively. Am J Cardiol 75:174-176, 1995.
  22. Myers L, Little T. Coronary splinting in cardiogenic shock. J Intervent Cardiol 9:65-67, 1996.
  23. Little T. Majcher G, Doorey A, Nguen M, Cassell J, Snyder J, Smith S, Scoblionko D, Singh S, Abopulmagd A. Immediate and long-term results of the Splinting for Acute Closure (SAC) Trial. Catheter Cardiovasc Diagn 38:341-344, 1966.
  24. Little T, Lunney L, Karim K. Vasoseal hemostasis following coronary interventions with Abciximab. Catheter Cardiovasc Diagn 44:405-6, 1996.

RESEARCH EXPERIENCE:

  • 1984 Cardiology research fellow, SUNY Buffalo.
  • 1989 Betaxolol in hypertension study.
  • 1990 SELECT TRIAL. Selecor’s Effect on Lowering blood pressure in patients with Elevated Cholesterol and Triglycerides.
  • 1991 SAC TRIAL Multicenter Splinting in Acute Closure Trial.
  • 1991 GUSTO TRIAL. Global Utilization of Streptokinase and TPA Trial.
  • 1993 CRAC TRIAL. Compliance Related Angioplasty Complications Trial.
  • 1993 REAF TRIAL. Randomized Easton Atrial Fibrillation Trial.
  • 1994 ELITE TRIAL. Evaluation of Losartin in the Elderly Trial.
  • 1995 PURSUIT TRIAL. A randomized double blind evaluation of the efficacy and safety of two dosing regimens of Integrelin vs. placebo for reducing mortality and myocardial reinfarction in patients with unstable angina or non-Q wave myocardial infarction.
  • 1996 CONVINCE TRIAL. Controlled Onset Verapamil Investigation of Cardiovascular Endpoints trial.
  • 1997 SYMPHONY TRIAL. Sibrafiban vs. Aspirin to yield maximum protection from ischemic heart events post acute coronary syndrome.
  • 1997 Reopro Readministration Registry.
  • 1999 2nd SYMPHONY TRIAL. Sibrafiban vs. Aspirin to yield maximum protection from ischemic heart events post acute coronary syndrome.
  • 1999 CAMBIAN TRIAL.
  • 1999 VALIANT TRIAL. Valsartan in Acute myocardial infarction.
  • 1999 AMISTAD TRIAL. Evaluation of the efficacy and safety of Adenosine as an adjunct to reperfusion therapy in the treatment of acute anterolateral MI.
  • 1999 ENABLE TRIAL. Endothelin Antagonist Bosentan for Lowering cardiac Events in heart failure.
  • 1999 PRESTO TRIAL. Prevention of REStenosis with Tranilast and its Outcomes. A placebo controlled trial.
  • 2000 SP LIPID TRIAL
  • 2000 CHRONO TRIAL
  • 2000 PRINCE TRIAL. Pravastatin Inflammation CRP Evaluation Trial.
  • 2001 PROVE IT (TIMI-22) TRIAL. Pravastatin or Atorvastatin Evaluation and Infection Therapy
  • 2001 OCTAVE TRIAL
  • 2002 IMPACT TRIAL
  • 2002 SOLAR TRIAL. 12 week, randomized, open-label, 3 arm parallel group multicenter phase IIIb study comparing the efficacy and safety of rosuvastatin with atorvastatin and simvastatin achieving NCEP ATP III LDL-C goals in high risk subjects with hypercholesterolemia in managed care setting.
  • 2002 CHARISMA TRIAL. Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance
  • 2002 A Single Center Clinical Evaluation of Carotid Stenting with Protection for the Treatment of Obstructive Carotid Artery Disease in a High Risk Subset of Patients for Carotid Endarterectomy.
  • 2003 ACTIVE TRIAL. Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events.
 
 
 

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